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A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
Paul Nioi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway
Jonathan M. Maher et al.
HEPATOLOGY (2007)
Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes
Mariann Plebuch et al.
CANCER LETTERS (2007)
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
Zheng Sun et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
Jacqui M. Marzec et al.
FASEB JOURNAL (2007)
Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes
Jianyong Zhang et al.
BIOCHEMICAL JOURNAL (2007)
Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells
Hoo Kyun Choi et al.
ENDOCRINE-RELATED CANCER (2007)
Microsomal glutathione transferase 1 in anticancer drug resistance
Katarina Johansson et al.
CARCINOGENESIS (2007)
ABCG2: determining its relevance in clinical drug resistance
Robert W. Robey et al.
CANCER AND METASTASIS REVIEWS (2007)
p53 suppresses the Nrf2-dependent transcription of antioxidant response genes
Raffaella Faraonio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents
Xiu Jun Wang et al.
CANCER RESEARCH (2006)
Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate
Mee-Hyang Kweon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
BCRP/ABCG2 levels account for the resistance to topoisomerase I inhibitors and reversal effects by gefitinib in non-small cell lung cancer
Seiji Nagashima et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
The consensus coding sequences of human breast and colorectal cancers
Tobias Sjoeblom et al.
SCIENCE (2006)
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism - A two-site interaction model for the Nrf2-Keap1 complex
Michael McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells
Ying Huang et al.
CANCER LETTERS (2006)
Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death
Anne Hanneken et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2006)
Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells
BS Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene
V Vollrath et al.
BIOCHEMICAL JOURNAL (2006)
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
KI Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
B Padmanabhan et al.
MOLECULAR CELL (2006)
Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 AND GST-π in human glioma
C Calatozzolo et al.
JOURNAL OF NEURO-ONCOLOGY (2005)
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells
V Materna et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
N Ballatori et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants
S Dhakshinamoorthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line
T Tarumoto et al.
EXPERIMENTAL HEMATOLOGY (2004)
57 varieties: the human cytochromes P450
DFV Lewis
PHARMACOGENOMICS (2004)
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
K Iida et al.
CANCER RESEARCH (2004)
Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins
J Cummings et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic
K Shiozawa et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia
M Mayerhofer et al.
CANCER RESEARCH (2004)
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
LA Doyle et al.
ONCOGENE (2003)
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Glutathion S transferase π indicates chemotherapy resistance in breast cancer
FX Su et al.
JOURNAL OF SURGICAL RESEARCH (2003)
Structure of a β-TrCP1-Skp1-β-catenin complex:: Destruction motif binding and lysine specificity of the SCFβ-TrCP1 ubiquitin ligase
G Wu et al.
MOLECULAR CELL (2003)
Prognostic significance of glutathione S-transferase-Pi in invasive breast cancer
JX Huang et al.
MODERN PATHOLOGY (2003)
Carbon monoxide inhibits apoptosis in vascular smooth muscle cells
XM Liu et al.
CARDIOVASCULAR RESEARCH (2002)
Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue
A Strassburg et al.
MOLECULAR PHARMACOLOGY (2002)
Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3)
N Zelcer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh et al.
GENES TO CELLS (2001)
Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer
T Oguri et al.
INTERNATIONAL JOURNAL OF CANCER (2001)
Cytochrome P450CYP1B1 protein expression: a novel mechanism of anticancer drug resistance
MCE McFadyen et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo
R Schiff et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
NAD(P)H:quinone oxidoreductase 1 (NQO1):: chemoprotection, bioactivation, gene regulation and genetic polymorphisms
D Ross et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2000)
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
HC Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues
D Sieger et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Mechanisms of action of quinone-containing alkylating agents I: NQO1-directed drug development
HD Beall et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2000)
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
J Wijnholds et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction
W Ax et al.
BIOCHEMICAL PHARMACOLOGY (2000)
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
JD Hayes et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2000)
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