期刊
DRUG DISCOVERY TODAY
卷 21, 期 11, 页码 1828-1834出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.07.013
关键词
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资金
- ETH Zurich
- Swiss National Science Foundation
- Deutsche Akademie der Naturforscher Leopoldina
- ERC Advanced Grant (ZAUBERKUGEL)
DNA-encoded chemical libraries have emerged as a powerful tool for hit identification in the pharmaceutical industry and in academia. Similar to biological display techniques (such as phage display technology), DNA-encoded chemical libraries contain a link between the displayed chemical building block and an amplifiable genetic barcode on DNA. Using routine procedures, libraries containing millions to billions of compounds can be easily produced within a few weeks. The resulting compound libraries are screened in a single test tube against proteins of pharmaceutical interest and hits can be identified by PCR amplification of DNA barcodes and subsequent high-throughput sequencing.
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