期刊
DRUG DISCOVERY TODAY
卷 21, 期 9, 页码 1367-1386出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.05.020
关键词
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资金
- European Union under the Marie Curie Career Integration Grant SuprHApolymers [PCIG14-GA-2013-631871]
- Marie Sklodowska-Curie Individual Fellowship - European Commission [MSCA-IF-2014-658351]
- China Scholarship Council
In vitro blood-brain barrier (BBB) models are indispensable screening tools for obtaining early information about the brain-penetrating behaviour of promising drug candidates. Until now, in vitro BBB models have focused on investigating the interplay among cellular components of neurovascular units and the effect of fluidic sheer stress in sustaining normal BBB phenotype and functions. However, an area that has received less recognition is the role of the noncellular basement membrane (BM) in modulating BBB physiology. This review describes the state-of-the-art on in vitro BBB models relevant in drug discovery research and highlights their strengths, weaknesses and the utility potential of some of these models in testing the permeability of nanocarriers as vectors for delivering therapeutics to the brain. Importantly, our review also introduces a new concept of engineering artificial BM platforms for reconstituting BBB models in vitro.
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