期刊
PLACENTA
卷 103, 期 -, 页码 94-103出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2020.10.017
关键词
Macrophages; Placenta; M1/M2 polarization; Infectious pregnancy
资金
- Fondation pour la Recherche M 'edicale postdoctoral fellowship [SPF20151234951]
- French Government under the Investissements d'avenir (Investments for the future) program [10-IAHU-03]
The review explores the diversity and functions of placental macrophages in order to better understand their dysfunctions during placental infections.
Placental macrophages are a heterogenous population of immune cells present throughout pregnancy. They are essential for maintenance of the homeostatic placenta environment and host defense against infections. The characterization of placental macrophages as well as their activation have been limited for a long time by the lack of convenient tools. The emergence of unbiased methods makes it possible to reappraise the study of placental macrophages. In this review, we discuss the diversity and the functions of placental macrophages to better understand their dysfunctions during placental infections.
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