期刊
PLACENTA
卷 104, 期 -, 页码 71-80出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2020.11.008
关键词
Gestational diabetes mellitus; Insulin like growth factor-1; Adipokine; Insulin/IGF-1 signalling; Glucose transporter-1; Fetal overgrowth
资金
- Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Puducherry, India [JIP/Res/Intra-PhD/Phs1/01/2016-17]
- Department of Biotechnology(DBT), India
The study showed that in women with GDM, levels of IGF-1 were increased while levels of adiponectin were decreased, potentially leading to increased GLUT-1 expression in the placenta through activation of the insulin/IGF-1 signaling pathway. This could have an impact on fetal growth.
Introduction: The placental glucose transporter - 1 (GLUT-1) is involved in the transplacental glucose transport to the fetus. GLUT-1 expressions are increased in diabetic pregnancies and associated with altered fetal growth. However, the factors regulating the GLUT-1 expressions are largely unknown. We hypothesised that maternal adipokines and insulin-like growth factor-1 (IGF1) modulate the placental expressions of GLUT-1 through the activation of insulin/IGF-1 signalling which may contribute to a fetal overgrowth in GDM. Methods: Maternal blood, cord blood and placental samples were collected from GDM and control pregnant women (CPW). The biochemical parameters, IGF1, adipokines, and high sensitive C- reactive protein were measured. We analysed the placental expressions of GLUT-1 and proteins related to insulin/IGF-1 signalling - insulin receptor -beta, insulin receptor substrate - 1, phosphatidylinositol-3-kinase p110 alpha, phospho Akt-1, phospho extracellular signal-regulated kinase 1/2, and nuclear factor-kappa B p65 in GDM and CPW. Results: Increased maternal IGF-1 and decreased adiponectin levels were found in the GDM women. Maternal IGF-1 levels were positively correlated, whereas adiponectin levels were negatively correlated with the birth weight of GDM newborns. Increased phosphorylation of Akt and ERK 1/2 was found in the placenta of GDM women. Placental expressions of GLUT-1 were significantly higher in the GDM women and positively correlated to the maternal IGF-1 levels in the GDM group. Discussion: Decreased maternal adiponectin and increased IGF-1 levels might have caused increased GLUT-1 expression via the increased activation of insulin/IGF-1 signalling in the placenta of GDM women which might have influenced the fetal growth.
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