期刊
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
卷 80, 期 -, 页码 57-64出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejmp.2020.09.022
关键词
Gold Nanoparticles; Radiation Therapy; Monte Carlo simulations; Dose enhancement
资金
- European Union through the Operational Program Human Resources Development, Education and Lifelong Learning (NSRF 2014-2020), under the call Supporting Researchers with an Emphasis on Young Researchers - Cycle B [MIS:5048154]
- Greek national funds through the Operational Program Human Resources Development, Education and Lifelong Learning (NSRF 2014-2020), under the call Supporting Researchers with an Emphasis on Young Researchers - Cycle B [MIS:5048154]
Purpose: Over the last decades, Gold Nanoparticles (AuNPs) have been presented as an innovative approach in radiotherapy (RT) enhancement. Several studies have proven that the irradiation of tumors containing AuNPs could lead to more effective tumor control than irradiation alone. Studies with low kV photons and AuNPs conclude in encouraging results regarding the level of radioenhancement. However, experimental and theoretical studies with MV photons report controversial findings concerning the correlation between dose enhancement effect and tumor cell killing. The great variation in the experimental protocols and simulations complicates the comparison of their outcomes and depicts the need for limiting the variety of investigated parameters. Our purpose is to point out a possible direction for building realistic Monte Carlo (MC) models that could end up with promising results in MV photons RT enhancement. Methods: We explored published in silico studies concerning AuNPs enhanced RT from 2010 to 2019. In this review, we discuss the different AuNPs and MV photon beams characteristics that have been reported and their effect in dose enhancement. Results: AuNPs size, concentration, type of distribution along with photon beams energy and the presence of flattening filter in linear accelerators seem to be the major parameters that determine AuNPs radioenhancement in silico. Conclusions: Prior to AuNPs clinical translation in photon radiotherapy, in silico studies should emphasize on nanodosimetry and track structure codes than condensed history ones. Toxicity estimation and biological aspects should be implemented in MC simulations so as to achieve accurate and realistic modelling of AuNPs driven RT.
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