期刊
DRUG DELIVERY
卷 23, 期 9, 页码 3350-3357出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2016.1178825
关键词
Breast cancer; mechanisms; multidrug resistance; nanoparticles
资金
- National Natural Science Foundation of China [81273707, 81173215]
- Ministry of Education in the New Century Excellent Talents [NECT-12-0677]
- Natural Science Foundation of Guangdong [S2013010012880]
- Science and Technology Program of Guangzhou [2014J4500005]
- Science Program of the Department of Education of Guangdong [2013KJCX0021, 2015KGJHZ012]
- Science and Technology Program of Guangdong [2015A050502027]
Breast cancer is a serious threat to women's health, because multidrug resistance (MDR) has hampered treatment and prognosis. Nanodelivery of anticancer agents is a new technology to be exploited in the treatment of patients, because it bypasses multispecific drug efflux transporters such as P-glycoprotein (ABCB1), multidrug resistance protein-1 (MRP1, ABCC1) and breast cancer resistance protein (BCRP, ABCG2). Drugs can be delivered to tumor tissue by passive and active tumor targeting strategies, which may reduce or reverse drug resistance. This review will mainly focus on MDR-associated proteins, as well as various nanoparticle formulations developed to overcome MDR in breast cancer.
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