期刊
PHARMACOLOGICAL RESEARCH
卷 163, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2020.105313
关键词
Sugiol; Diterpenoid; Anticancer; Natural products; Pharmaco therapeutic
资金
- Korea Industrial Complex Corp.(KICOX, NTIS) [1415165722]
- Dongguk University Research Fund of 2019 [S-2020-G0001-00057]
Understanding the interaction between natural product structural diversity, cellular metabolism, and infectious disease targets remains challenging. Inflammation plays a crucial role in the human healing process, and drugs derived from plant products, including sugiol, are being actively researched. Despite evidence of efficacy and safety, sugiol has not been approved as a therapeutic agent due to low bioavailability and insolubility in an aqueous environment.
Understanding how the natural products structural diversity interacts with cellular metabolism and infectious disease targets remains a challenge. Inflammation is an important process in the human healing response in which the tissues respond to injuries induced by many agents, including pathogens. In recent years, several drugs derived from plant products have been developed, and current drug research is actively investigating the pharmacotherapeutic role of natural products in advanced multimodal inflammatory disease targeting. Sugiol, a diterpenoid, can act as an antimicrobial, antioxidant, anti-inflammatory, anti-carcinoma, antiviral, and cardiovascular agent. Until now, there have been no updates on the pharmacotherapeutic advancement of sugiol. Herein, we correlate the diverse molecular pathways in disease prevention involving sugiol. We also discuss the origins of its structural diversity and summarize new research directions toward exploring its novel effective future uses. Despite much evidence of its efficacy and safety, the sugiol has not yet been approved as a therapeutic agent due to its low bioavailability, and insolubility in an aqueous environment. The aim of this review is to renew and update noteworthy information on the pharmacotherapeutic characteristics of sugiol to approach different advanced strategies employed in the context of natural nurturing-based biomedicine.
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