期刊
DRUG DELIVERY
卷 23, 期 6, 页码 1892-1901出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2016.1143058
关键词
Bioavailability; degenerative disease; delivery system; diabetes; stomach
资金
- National Council for Research and Development (CNPq - Brazil)
- Natural Sciences and Engineering Research Council (NSERC) of Canada
Several reports have indicated a positive correlation between the consumption of anthocyanins (ACN) and biomarkers relating to the improvement of type 2 diabetes (T2D). However, the results from in vitro studies often do not translate into clinical evidence. Potential causes of these discrepancies are experimental conditions that lack physiological relevancy; extensive degradation of these compounds in vivo due to changes in pH and metabolism; and a short residence time in the absorption window in relation to the absorption rate. Here, gastroretentive systems (GRS) are proposed as a strategy to overcome the limitations in ACN delivery and to reduce the existing bench-to-subject gap. This review summarizes recent literature on the use of ACN for the management and control of T2D, followed by GRS platforms to promote a sustained release of ACN for increased health benefits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据