期刊
PEST MANAGEMENT SCIENCE
卷 77, 期 5, 页码 2403-2414出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ps.6269
关键词
natural compounds; terpenoid; antifungal agents; biological screening; crop protection; sesamol
资金
- Region Hauts de France
- Yncrea Hauts de France
- French Government
A study evaluated naturally occurring terpenoids and phenolic compounds as crop protection compounds against Zymoseptoria tritici. Sesamol esters were discovered as promising antifungal agents with high activity and no cytotoxicity against human cells, after some hemisynthetic modifications.
BACKGROUND: Research into environmentally friendly alternatives to conventional plant protection products, to promote sustainable agriculture and healthy food, is strongly encouraged. RESULTS: In this context, 20 naturally occurring terpenoids and phenolic compounds were selected and evaluated in vitro as crop protection compounds against Zymoseptoria tritici, the causal agent of Septoria tritici blotch of wheat. After selection of the most active compounds, some hemisynthetic modifications were conducted to modify their lipophilicity. These modifications led to the discovery of sesamol esters as promising antifungal agents, with IC50 around 10 mu g/mL and a total absence of cytotoxicity against human cells. CONCLUSION: These sesamol-based derivatives should be selected for further evaluations in planta to validate their use as wheat crop protection agents. Moreover, the importance of a balanced hydrophily/lipophilicity ratio should be further studied. (c) 2021 Society of Chemical Industry
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