期刊
DRUG AND ALCOHOL DEPENDENCE
卷 162, 期 -, 页码 51-55出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2016.02.024
关键词
Mortality; Injection drug use; Vancouver; Non-fatal overdose
资金
- US National Institutes of Health [U01DA038886, R01DA021525]
- Canada Research Chairs program through a Tier 1 Canada Research Chair in Inner City Medicine
- Canadian Institutes of Health Research [MSH-141971]
Objectives: To examine the relationship between non-fatal overdose and risk of subsequent fatal overdose. Methods: We assessed risk factors for overdose death among two prospective cohorts of persons who inject drugs (PWID) in Vancouver, Canada. Extended Cox regression was used to examine if reports of non-fatal overdose were associated with the time to fatal overdose while adjusting for other behavioral, social and structural confounders. Results: Between May, 1996 and December, 2011, 2317 individuals were followed for a median of 60.8 months. In total, 134 fatal overdose deaths were identified for an incidence density of 8.94 (95% confidence interval [CI]: 7.55-10.59) deaths per 1000 person-years. During the study period there were 1795 reports of non-fatal overdose. In a multivariate model, recent non-fatal overdose was independently associated with the time to overdose mortality (adjusted hazard ratio [AHR] = 1.95; 95% CI: 1.17-3.27). As well, there was a dose response effect of increasing cumulative reports of non-fatal overdose on subsequent fatal overdose. Conclusion: Reports of recent non-fatal overdose were independently associated with subsequent overdose mortality in a dose-response relationship. These findings suggest that individuals reporting recent non-fatal overdose should be engaged with intensive overdose prevention interventions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据