期刊
PEDIATRIC BLOOD & CANCER
卷 68, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/pbc.28865
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资金
- NCI NIH HHS [T32 CA060441] Funding Source: Medline
Chronic myelomonocytic leukemia (CMML) is a common myelodysplastic syndrome/myeloproliferative disorder in the elderly, but rare in adolescents. This case report describes an adolescent with monosomy 7 CMML presenting with central diabetes insipidus (DI), treated with venetoclax and decitabine as a bridge to hematopoietic stem cell transplantation (HSCT).
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome (MDS)/myeloproliferative disorder most commonly seen in the elderly. We describe an adolescent with monosomy 7 CMML presenting as central diabetes insipidus (DI), who was treated with venetoclax and decitabine as a bridge to hematopoietic stem cell transplantation (HSCT). Central DI is a rare manifestation of monosomy 7-associated MDS including CMML, itself a rare manifestation of GATA2 deficiency, particularly in children. Venetoclax/decitabine was effective for treatment of CMML as a bridge to HSCT.
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