期刊
PARASITES & VECTORS
卷 14, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13071-020-04528-x
关键词
Apicomplexa; Behavioral manipulation; Complex life cycle; Extended phenotypes; Parasitic manipulation; Protozoa
资金
- Human Frontier Science Program [RGP0062/2018]
- Alexander von Humboldt Foundation
Toxoplasma gondii is a protozoan parasite that manipulates the behavior of its intermediate hosts to increase the chances of transmission to its definitive host, cats. Understanding the mechanisms of this behavioral manipulation is crucial for studying host-parasite relationships.
Toxoplasma gondii is a protozoan parasite with a complex life cycle and a cosmopolitan host range. The asexual part of its life cycle can be perpetually sustained in a variety of intermediate hosts through a combination of carnivory and vertical transmission. However, T. gondii produces gametes only in felids after the predation of infected intermediate hosts. The parasite changes the behavior of its intermediate hosts by reducing their innate fear to cat odors and thereby plausibly increasing the probability that the definitive host will devour the infected host. Here, we provide a short description of such parasitic behavioral manipulation in laboratory rodents infected with T. gondii, along with a bird's eye view of underpinning biological changes in the host. We also summarize critical gaps and opportunities for future research in this exciting research area with broad implications in the transdisciplinary study of host-parasite relationships.
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