期刊
PANCREATOLOGY
卷 21, 期 1, 页码 103-114出版社
ELSEVIER
DOI: 10.1016/j.pan.2020.11.022
关键词
Circulating tumour cells; Pancreatic cancer; Cancer survival; Cancer staging; Portal vein blood sampling
资金
- Gastroenterological Society of Australia
- Pankind (The Australian Pancreatic Cancer Foundation)
CTCs are commonly detected in the peripheral circulation of PC patients, and may be associated with prognosis and disease stage. Portal vein blood contains more CTCs compared to peripheral blood, with different enrichment techniques yielding varied detection rates.
Background: The detection and quantification of circulating tumour cells (CTCs) in pancreatic cancer (PC) has the potential to provide prognostic information. The aim of this review was to provide an overview of the literature surrounding CTCs in PC. Methods: A systematic literature review on CTCs in PC between 2005-2020 was performed. Data based on peripheral vein samples were used to determine the positivity rate of CTCs, their prognostic significance and their relative numbers compared to portal vein (PV) samples. Results: The overall CTC detection rate in forty-four articles was 65% (95%CI: 55-75%). Detection rate for CellSearch was 26% (95%CI: 14-38%), which was lower than for both filtration and microfluidic techniques. In nine studies with >50 patients, overall survival was worse with CTC positivity (HR 1.82; 95%CI: 1.61-2.05). Five of seven studies which described PV CTC collection provided patient-level data. PV CTC yield was 7.7-fold (95%CI 1.35-43.9) that of peripheral blood. Conclusions: CTCs were detected in the peripheral circulation of most patients with PC and may be related to prognosis and disease stage. PV blood contains more CTCs than peripheral blood sampling. This review points to the maturation of techniques of CTC enrichment, and its evidence base for eventual clinical deployment. (C) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.
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