期刊
DRUG AND ALCOHOL DEPENDENCE
卷 158, 期 -, 页码 181-185出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2015.11.024
关键词
Cocaine; Biochemical marker; Cytokines; IL-6; IL-10
Background: Cocaine abuse is capable of activating the innate immune system in the CNS resulting in deregulation of homeostasis between pro and antiinflammatory cytokines. The aim of this study was to investigate serum levels of pro and antiinflammatory cytokines, IL-6 and IL-10 respectively, in cocaine users from a young population-based sample. Methods: This is a case-control study nested in a cross-sectional population-based survey, with individuals of 18 and 35 years old. Two groups were selected: 24 healthy controls and 12 subjects who reported cocaine use. Serum IL-6 and IL-10 were measured by ELISA using a commercial kit. Results: There was a statistically significant increase in IL-6 (p=0.037) and decrease in IL-10 (p = 0.007) serum levels, between cocaine users and the control group. There was also an increase in the ratio IL-6/IL-10 (p = 0.013) among cocaine users individuals, when compared to the control group. Conclusions: Our results suggest that cocaine users showed an activation of the immune system when compared a control group, demonstrating a disruption in the balance of pro and antiinflammatory cytokines. Thus, peripheral cytokines may represent a putative biomarkers for cocaine users, contributing to the development of diagnosis and effective treatments. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据