Predictors of permanent pacemaker implantation after ACURATE neo transcatheter heart valve implantation

Background Rates of permanent pacemaker implantation (PPI) have been low using the self-expanding ACURATE neo device, but data regarding risk factors of PPI for this specific device are scarce. Methods The study cohort consisted of patients (n = 1000) with severe aortic stenosis undergoing transfemoral transcatheter aortic valve implantation (TAVI) using the ACURATE neo prosthesis in our center between May 2012 and December 2019. For the present analysis, we excluded patients with previous permanent pacemaker (n = 110), high-grade AV block prior to TAVI (n = 3), and patients requiring conversion to surgical valve replacement (n = 4) or the implantation of a second prosthesis as valve-in-valve (n = 15). Preexisting conduction abnormalities were determined, and the implantation depth of the prosthesis was measured on final angiography. Differences across quartiles based on the original consecutive cohort were analyzed with respect to implantation depth and PPI rate. Predictors of PPI were identified using logistic regression. Results The PPI rate was 10%. Preexisting AV block I degrees, right bundle branch block (RBBB), and the implantation depth were independent predictors of PPI. Across quartiles, the implantation depth differed significantly with lowest values in the last quartile, whereas differences of PPI rates across quartiles were not statistically significant, but showed a notable decrease in the last quartile. Conclusion Preexisting RBBB, AV block I degrees, and low implantation depth were independent predictors of PPI following TAVI using the ACURATE neo device. Instead of deliberately aiming at a high position, avoidance of a low implantation depth may represent a reasonable compromise to reduce the rate of PPI without increasing the risk of malpositioning.

Automated summary

Background rates of PPI with the self-expanding ACURATE neo device have been low, but data on risk factors for PPI with this specific device are scarce. In a study of patients undergoing TAVI using the ACURATE neo prosthesis, preexisting RBBB, AV block I degrees, and low implantation depth were identified as independent predictors of PPI. Therefore, avoiding overly high implantation depth may be a reasonable compromise for reducing the rate of PPI without increasing the risk of malpositioning.