期刊
ORGANOMETALLICS
卷 40, 期 1, 页码 72-82出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.0c00728
关键词
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资金
- University of Arkansas
- NIHNIGMS [GM132906]
- Arkansas Statewide Mass Spectrometry Facility (NIH-NIGMS) [P30 GM103450]
- IASBS Research Council [G2020IASBS32629]
- Iran National Science Foundation [97007977]
- Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences [B98035]
- National Science Foundation [CHE-1726630]
- University of Oklahoma
Cationic cycloplatinated(II) complexes with bisphosphine ligands showed higher cytotoxicity compared to cisplatin across various cancer cell lines, especially complex 3 exhibiting excellent antiproliferative activity. The stability of these complexes in biological environments and their mode of interaction with DNA were also investigated.
A family of cationic cycloplatinated(II) complexes [Pt(dfppy)(P<^>P)]Cl incorporating bisphosphine ligands was prepared: (dfppy = 2-(2,4-difluorophenyl)pyridine; P<^>P = bis(diphenylphosphino)methane (1, dppm), 1,2-bis(diphenylphosphino)ethane (2, dppe), 1,2-bis(diphenylphosphino)benzene (3, dppbz)). The complexes were characterized by means of several analytical and spectroscopic methods. These complexes displayed acceptable stability in biological environments, which was confirmed by NMR, HR ESI-MS, and UV-vis techniques. The antiproliferative properties of these complexes were evaluated by the National Cancer Institute (NCI) against 60 different human tumor cell lines such as leukemia, melanoma, lung, colon, brain, ovary, breast, prostate, and kidney. These complexes showed higher cytotoxicity in comparison to cisplatin against a wide variety of cancer cell lines such as K-562 (leukemia), HOP-92 (lung), HCT-116 (colon), OVCAR-8 (ovarian), PC-3 (prostate), MDA-MB-468 (breast), and melanoma cancer cell lines. Complex 3, as the most potent compound in this study, furnished an excellent antiproliferative activity in comparison to cisplatin against Hela, SKOV3, and MCF-7 cancer cell lines. The main mode of the interactions of 1-3 with DNA was also determined using molecular docking studies.
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