期刊
ORGANIC LETTERS
卷 23, 期 3, 页码 1054-1059出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04254
关键词
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资金
- Science and Technology Innovation Commission of Shenzhen Municipality [JCYJ20180302180256215]
- Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]
- Guang-dong Provincial Key Laboratory of Catalysis [2020B121201002]
- National Natural Science Foundation of China [22078263, Y01216129]
A synergetic copper/photoredox catalyzed ATRA of styrenes and thiosulfonates has been developed, allowing for the construction of benzylic quaternary carbon centers. The mild conditions and high substrate compatibility make this method applicable for derivatizing bioactive natural products and installing fluorophores across alkenes. Mechanistic studies have identified sulfonyl radicals as key intermediates in the transformation.
A synergetic copper/photoredox catalyzed ATRA of styrenes and thiosulfonates is developed. Besides aryl ethylenes, the challenging alpha-substituted styrenes were employed to construct the benzylic quaternary carbon centers. Owing to the mild conditions as well as the high level of substrate compability, this ATRA could be applied to derivatize bioactive natural products in late stage, and to install fluorophores across alkenes. The mechanistic studies reveal sulfonyl radicals as the key intermediate in the transformation.
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