期刊
ORGANIC LETTERS
卷 23, 期 2, 页码 300-304出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03774
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资金
- Labex ARCANE
- Labex CBH-EUR-GS [ANR-17-EURE-0003]
- NanoBio-ICMG platforms [FR 2607]
- Departement de Chimie Moleculaire
- Institut de Chimie des Subtances Naturelles
Bicyclic compounds with a quaternary stereogenic center were synthesized using asymmetric intramolecular Buchner reaction with high yields and enantioselectivity. X-ray crystallography revealed unexpected behavior in the crystal structure, including equilibrating valence isomers in the solid state, and DFT calculations supported these findings.
Bicyclic compounds bearing a quaternary stereogenic center have been obtained using asymmetric intramolecular Buchner reaction with excellent yields and level of enantioselectivity. X-ray crystallography determination of the absolute configuration of one product has led to the serendipitous observation of an unusual behavior within the crystal structure, with equilibrating norcaradiene and cycloheptatriene valence isomers at the solid state, as well as an even more unexpected intermediate form. DFT calculations were performed to support these observations.
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