Visible Light/Tertiary Amine Promoted Synergistic Hydroxydifluoroacetamidation of Unactivated Alkenes under Air

An efficient and novel method for regioselective hydroxydifluoroacetamidation of alkenes with bromodifluor-oacetamides has been achieved via a tandem radical pathway mediated by photoredox catalysis under metal-free conditions. This transformation proceeded smoothly in the presence of Rhodamine 6G, affording a series of alpha,alpha-difluoro-gamma-hydroxyacetamides in moderate to excellent yields. The significant advantages of this protocol are the low-cost photocatalyst, readily available starting materials, synthetic convenience, and wide functional group compatibility.

Automated summary

This efficient and novel method involves regioselective hydroxydifluoroacetamidation of alkenes with bromodifluoroacetamides through a tandem radical pathway mediated by photoredox catalysis under metal-free conditions. The reaction, using Rhodamine 6G as the photocatalyst, produces a series of alpha,alpha-difluoro-gamma-hydroxyacetamides in moderate to excellent yields, demonstrating the advantages of low-cost photocatalyst, readily available starting materials, synthetic convenience, and wide functional group compatibility.