N2H4-H2O Enabled Umpolung Cyclization of o-Nitro Chalcones for the Construction of Quinoline N-Oxides

Umpolung is a unique strategy which converts the property of an atom into the opposite one. An efficient and general method for the construction of quinoline N-oxides via umpolung of carbonyl groups was developed from ortho-nitro chalcones and hydrazine in basic conditions. The strategy is transition-metal free and has good functional group tolerance, environmental friendliness, as well as mild reaction conditions with nitrogen gas as the byproduct.

Automated summary

Umpolung is a unique strategy that converts the property of an atom into the opposite one. An efficient and general method for constructing quinoline N-oxides from ortho-nitro chalcones and hydrazine has been developed under transition-metal free conditions. The strategy shows good functional group tolerance, environmental friendliness, and mild reaction conditions, with nitrogen gas as the byproduct.