期刊
ORGANIC LETTERS
卷 23, 期 3, 页码 762-766出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03991
关键词
-
资金
- National Natural Science Foundation of China [81821004, 21871011, U1604285, 21877206]
- 111 Project [D17007]
Described here is a Cu-catalyzed [2 + 2 + 1] modular synthesis of full-substituted beta-pyrrolinones from simple amines, alkynes, and alpha-diazo-beta-ketoesters. This approach enables the direct synthesis of full-substituted beta-pyrrolinones, which were hardly constructed by traditional synthetic strategies.
Described here is a Cu-catalyzed [2 + 2 + 1] modular synthesis of full-substituted beta-pyrrolinones from simple amines, alkynes, and alpha-diazo-beta-ketoesters. This approach involving the regioselective C-nucleophilic attack of enamines, uncommon C-nucleophilic addition to ketenes, and umpolung of imines enables the direct synthesis of full-substituted beta-pyrrolinones, which were hardly constructed by traditional synthetic strategies.
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