Carbene-Catalyzed Enantioselective Synthesis of γ-Keto-β-silyl Esters and Amides

A variety of gamma-keto-beta-silyl esters and amides, most with extremely high enantioselectivities, were efficiently prepared via a carbene-catalyzed formal [4 + 2] annulation followed by ring opening with nucleophiles. The resulting compounds from this one-pot strategy can be easily converted into enantioenriched beta,sigma-dihydroxyl esters.