4.8 Article

In Situ Generation of Unstable Difluoromethylphosphonate-Containing Diazoalkanes and Their Use in [3+2] Cycloaddition Reactions with Vinyl Sulfones

期刊

ORGANIC LETTERS
卷 23, 期 3, 页码 1130-1134

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00150

关键词

-

资金

  1. National Natural Science Foundation of China [21761132021]
  2. German Research Foundation [RO 362/74-1]

向作者/读者索取更多资源

An efficient route for the synthesis of functionalized fluorinated pyrazolines derivatives was developed by conducting a [3+2] cycloaddition reaction of unstable difluoromethylphosphonate-containing diazoalkanes with vinyl sulfones under simple reaction conditions. The difluoro diazalkanes were generated in situ using t-BuONO for the diazotization of (beta-amino-alpha,alpha-difluoroethyl)phosphonates, demonstrating good stability and reactivity.
A [3 + 2] cycloaddition reaction of unstable difluoromethylphosphonate-containing diazoalkanes with vinyl sulfones under simple reaction conditions is developed, which provides an efficient route toward functionalized fluorinated pyrazolines derivatives in good chemical yields. The difluoro diazoalkanes are generated in situ using t-BuONO for the diazotization of (beta-amino-alpha,alpha-difluoroethyl)phosphonates, and their stabilities and reactivities were carefully investigated.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据