期刊
ORGANIC LETTERS
卷 22, 期 23, 页码 9319-9324出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03542
关键词
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资金
- National Natural Science Foundation of China [21702060]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- Program of Introducing Talents of Discipline to Universities [B16017]
- Fundamental Research Funds for the Central Universities
Herein, we disclose a nickel-catalyzed three-component reaction of internal enamide, diethoxymethylsilane, and aryl iodide to provide expedient access to benzylic amide derivatives. The protocol features a broad substrate scope with a moderate to excellent isolated yield under the mild condition. The high regioselectivity of Ni-catalyzed enamide hydroarylation can be attributed to the directing effect by the prefunctionalized nitrogen-containing group on the alkenes.
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