期刊
ORGANIC LETTERS
卷 22, 期 23, 页码 9163-9168出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03077
关键词
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资金
- Natural Science Foundation of Zhejiang Province [LY21B020003]
- National Natural Science Foundation of China [21602022, 21672232, 21977106, 21632008]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA12020375, XDA12050411]
- Chengdu Talents Program
- 1000 Talents Program of Sichuan Province
- Science and Technology Program of Sichuan Province [2018JY0345]
- Jinhua Branch of Sichuan Industrial Institute of Antibiotics [1003]
- Chengdu University [2081915037]
- Chenghua District Talents Program
An efficient Rh(III)-catalyzed C-H alkenylation/directing group migration cascade between indoles and alkynes for the assembly of tetrasubstituted alkenes is reported. The carbamoyl directing group migrates to the carbon of the alkene moiety of the products through rare Rh-catalyzed C-N bond cleavage after the C-H alkenylation step and thus acts as an internal amidation reagent. This protocol shows broad substrate scope, excellent regio/stereoselectivity, and good to excellent yields.
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