期刊
ORGANIC LETTERS
卷 23, 期 3, 页码 908-913出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04118
关键词
-
资金
- National Natural Science Foundation of China [21877117, 91953203, 21907103]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2018ZX09711002-005]
- Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences [XDA12040330, XDA12050405]
- Shanghai Commission of Science and Technology [18431907100]
By utilizing a diversity-oriented synthesis strategy with alpha,beta-unsaturated carbonyl compounds, DNA-compatible transformations for various heterocyclic scaffolds have been established, paving the way for preparing DNA-encoded libraries with more extensive chemical space.
Taking advantage of the diversity-oriented synthesis strategy with alpha,beta-unsaturated carbonyl compounds, we have successfully established the DNA-compatible transformations for various heterocyclic scaffolds. The ring-closure reactions for pyrrole, pyrrolidine, pyrazole, pyrazoline, isoxazoline, pyridine, piperidine, cyclohexenone, and 5,8-dihydroimidazo[1,2-a]pyrimidine were elegantly demonstrated in a DNA-compatible format. These efforts paved the way for preparing DNA-encoded libraries with more extensive chemical space.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据