期刊
ORGANIC LETTERS
卷 23, 期 3, 页码 1081-1085出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04296
关键词
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资金
- National Natural Science Foundation of China [21902083, 22074079]
- College Students Innovation and Entrepreneurship Training Project of Shandong Province [S201910446044]
- Natural Science Foundation of Shandong Province [ZR2020QB130, ZR2018MB014]
- Talent Program Foundation of Qufu Normal University [6132, 6125]
The electroreductive-induced C3 pyridylation of quinoxalin-2(1H)-ones with cyanopyridines provides a convenient, efficient, and gram-scale synthesis strategy for a series of new types of potential bidentate nitrogen ligands, achieving yields of over 95% in more than 36 examples.
The construction of functional N-containing active biomolecules and bidentate nitrogen ligands by electroreductive pyridylation of N-heteroaromatics is an eye-catching task and challenge. A simple and practical electroreductive-induced C3 pyridylation of quinoxalin-2(1H)-ones with readily available cyanopyridines is reported. More than 36 examples are supplied, and the reaction performed in >95% yield. The present protocol provides a convenient, efficient, and gram-scale synthesis strategy for a series of new types of potential bidentate nitrogen ligands.
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