Photoredox-Catalyzed Decarboxylative Cross-Coupling of α-Amino Acids with Nitrones

A decarboxylative cross-coupling reaction of alpha-amino acids with nitrones via visible-light-induced photoredox catalysis has been established for easy access to beta-amino hydroxylamines and vicinal diamines with structural diversity, which is featured with simple operation, mild conditions, readily available alpha-amino acids, and a broad scope of nitrone substrates. The application of this protocol can furnish efficient synthetic strategies for some valuable vicinal diamine-containing molecules.

Automated summary

A decarboxylative cross-coupling reaction of alpha-amino acids with nitrones via visible-light-induced photoredox catalysis has been established, providing easy access to beta-amino hydroxylamines and vicinal diamines with structural diversity. This protocol offers efficient synthetic strategies for some valuable molecules containing vicinal diamine groups.