期刊
ONCOGENE
卷 40, 期 3, 页码 475-491出版社
SPRINGERNATURE
DOI: 10.1038/s41388-020-01560-0
关键词
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资金
- McGill faculty of medicine Gosselin Graduate Studentship
- McGill faculty of medicine
- Canada Research Chair of Molecular Oncology
- Terry Fox Research Institute Program Group Grant
- National Institute of Health Research
- Canadian Institute of Health Research the Canadian Cancer Society Impact Grant
- Cancer Research Society
Understanding breast cancer progression, metastasis, and therapeutic discovery is crucial. The MMTV-PyMT mouse model is a valuable tool that helps researchers better understand the molecular basis of breast cancer.
Breast cancer is associated with the second highest cancer-associated deaths worldwide. Therefore, understanding the key events that determine breast cancer progression, modulation of the tumor-microenvironment and metastasis, which is the main cause of cancer-associated death, are of great importance. The mammary specific polyomavirus middle T antigen overexpression mouse model (MMTV-PyMT), first published in 1992, is the most commonly used genetically engineered mouse model (GEMM) for cancer research. Mammary lesions arising in MMTV-PyMT mice follow similar molecular and histological progression as human breast tumors, making it an invaluable tool for cancer researchers and instrumental in understanding tumor biology. In this review, we will highlight key studies that demonstrate the utility of PyMT derived GEMMs in understanding the molecular basis of breast cancer progression, metastasis and highlight its use as a pre-clinical tool for therapeutic discovery.
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