期刊
NUTRITION
卷 81, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2020.110931
关键词
Acute radiation syndrome; Radiation-induced intestinal injury; Oxidative stress; Vitamin C insufficiency
资金
- Japan Ministry of Defense
This study demonstrated that nutritionally sufficient vitamin C exerts a radioprotective effect against radiation-induced gastrointestinal syndrome, but has minimal impact on hematopoietic syndrome.
Objectives: Accidental exposure to high-dose radiation causes life-threatening acute radiation syndrome, features that include gastrointestinal syndrome (GIS) and hematopoietic syndrome (HS). Administration of vitamin C (VC), a free radical scavenger, has been reported to increase survival of mice in GIS and HS models. The effect of nutritional VC status on radiation injury remains unknown because, unlike humans, mice can synthesize VC. The aim of this study was to investigate the effect of VC insufficiency on acute radiation syndrome using senescence marker protein 30 (SMP30)/gluconolactonase knockout (SMP30-KO) mice. Methods: SMP30-KO mice, which cannot synthesize VC, were given water with or without sufficient VC supplementation, and were analyzed in GIS and HS models. Results: In the GIS model, in which bone marrow failure is rescued by bone marrow transplantation, VC insufficient mice had a lower survival rate than VC-sufficient mice. The intestine of VC-insufficient GIS mice showed epithelial cell atrophy, inflammatory cell infiltration, and decreased crypt cell proliferation. We observed rapid VC oxidation after total body irradiation in the intestine of mice supplemented with VC -sufficient water. In the HS model, which was not combined with bone marrow transplantation, there was no difference in survival between VC-insufficient and-sufficient mice. Conclusion: The results of this study demonstrated that nutritionally sufficient VC exerts a radioprotective effect against radiation-induced GIS. (c) 2020 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据