期刊
NUCLEIC ACIDS RESEARCH
卷 49, 期 D1, 页码 D325-D334出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkaa1113
关键词
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资金
- National Human Genome Research Institute [U41 HG02273, U41 HG001315, U24 HG002223, U41HG000739, HG 003751, U41HG007822, U41HG002273, HG002659, HG010859, HG 000330, HG 002273]
- National Institute of General Medical Sciences [1R24GM137770-01, R01GM080646, P20GM103446, U01GM120953]
- National Institutes of Health [GM089636]
- National Science Foundation [1565146, 1458400]
- EMBL core funds
- UK Medical Research Council [MR/N030117/1, MR/S000453/1]
- Biotechnology and Biological Sciences Research Council [BB/N00521X/1, BB/N019172/1, BB/L024136/1, BB/M011674/1]
- Gene Regulation
- Research Council of Norway [247727]
- Alzheimer's Research UK [ARUK-NAS2017A-1]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- European Molecular Biology Laboratory core funds [OTAR-044, OTAR02-048]
- Wellcome Trust grant INVAR [212925/Z/18/Z]
- National Heart, Lung, and Blood Institute [HL 64541, HL 541]
- National Eye Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Mental Health of the National Institutes of Health [U24HG007822]
- Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI
- European Molecular Biology Laboratory core funds
- US National Human Genome Research Institute [U24-HG002223]
- UK Biotechnology and Biological Sciences Research Council [BB/P024610, BB/P024602]
- National Science Foundation award [IOS] [1127112, 1340112]
- Wellcome Trust [108433/Z/15/Z, 104967/Z/14/Z]
- Ensemble Effort for the Knowledge Commons (GREEKC) COST Action [CA15205]
- Wellcome Trust [212925/Z/18/Z, 108433/Z/15/Z] Funding Source: Wellcome Trust
- BBSRC [BB/N019172/1, BB/N00521X/1, BB/L024136/1, BB/M011674/1] Funding Source: UKRI
- MRC [MR/S000453/1, MR/N030117/1] Funding Source: UKRI
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1565146, 1458400] Funding Source: National Science Foundation
The Gene Ontology Consortium has made advancements in the last two years, such as improving the GO-CAM annotation framework, increasing the number of annotations and annotated gene products, and reviewing older annotations for consistency.
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.
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