期刊
NEW PHYTOLOGIST
卷 229, 期 5, 页码 2470-2491出版社
WILEY
DOI: 10.1111/nph.17039
关键词
Agaricus bisporus; ascomycetes; basidiomycetes; Cryptococcus; Microbotryum; Neurospora tetrasperma; Podospora anserina; sex chromosomes
资金
- Marie Curie European grant [PRESTIGE-2016-4-0013]
- NIH [R15GM119092]
- Louis D. Foundation award
- EvolSexChrom ERC advanced grant [832352]
- European Research Council (ERC) [832352] Funding Source: European Research Council (ERC)
Genomic regions determining sexual compatibility often display recombination suppression, which can extend beyond the genes determining sexes or mating types, maintaining the multiallelic combinations required for correct compatibility determination. Recent evidence shows expansions of recombination suppression beyond mating-type genes in fungi, which have been little studied and may be more pervasive than commonly thought. The study of recombination suppression in fungi could contribute to our understanding of recombination suppression expansion across a broader range of organisms.
Genomic regions determining sexual compatibility often display recombination suppression, as occurs in sex chromosomes, plant self-incompatibility loci and fungal mating-type loci. Regions lacking recombination can extend beyond the genes determining sexes or mating types, by several successive steps of recombination suppression. Here we review the evidence for recombination suppression around mating-type loci in fungi, sometimes encompassing vast regions of the mating-type chromosomes. The suppression of recombination at mating-type loci in fungi has long been recognized and maintains the multiallelic combinations required for correct compatibility determination. We review more recent evidence for expansions of recombination suppression beyond mating-type genes in fungi ('evolutionary strata'), which have been little studied and may be more pervasive than commonly thought. We discuss testable hypotheses for the ultimate (evolutionary) and proximate (mechanistic) causes for such expansions of recombination suppression, including (1) antagonistic selection, (2) association of additional functions to mating-type, such as uniparental mitochondria inheritance, (3) accumulation in the margin of nonrecombining regions of various factors, including deleterious mutations or transposable elements resulting from relaxed selection, or neutral rearrangements resulting from genetic drift. The study of recombination suppression in fungi could thus contribute to our understanding of recombination suppression expansion across a broader range of organisms.
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