期刊
NEW PHYTOLOGIST
卷 230, 期 3, 页码 1017-1033出版社
WILEY
DOI: 10.1111/nph.17211
关键词
cereal crops; IDS1; miR172; reactive oxygen species (ROS) homeostasis; salt tolerance
资金
- National Key R&D Program of China [2019YFD1000700, 2019YFD1000703]
- National Key Special Programs for Breeding from the Ministry of Science and Technology of China [2016YFD0100403]
- Natural Science Foundation of China [31901595]
- National Transgenic Major Program [2019ZX08010-004]
The miRNA miR172 acts as a positive regulator of salt tolerance in cereal crops, especially in maintaining ROS homeostasis during salt stress by balancing the expression of a group of ROS-scavenging genes.
Salt stress triggers the overdose accumulation of reactive oxygen species (ROS) in crop plants, leading to severe oxidative damage to living tissues. MicroRNAs (miRNAs) act as master regulators orchestrating the stress responsive regulatory networks as well as salt tolerance. However, the fundamental roles of miRNAs in modulating salt tolerance in cereal crops, especially in salt-triggered ROS scavenging remain largely unknown. Through small RNA sequencing, a salt-responsive miRNA, miR172 was identified in rice. Further, by generating the miR172-overexpression or MIR172 gene loss-of-function mutant lines, the biological significance of miR172 and its downstream signaling pathways related to salt tolerance were defined. We demonstrated that miR172 is a positive regulator of salt tolerance in both rice and wheat. More interestingly, miR172a and miR172b, but not miR172c or miR172d are involved in salt stress response, emphasizing the functional differentiation within miR172 family members. Further evidence uncovers a novel miR172/IDS1 regulatory module that functions as a crucial molecular rheostat in maintaining ROS homeostasis during salt stress, mainly through balancing the expression of a group of ROS-scavenging genes. Our findings establish a direct molecular link between miRNAs and detoxification response in cereal crops for improving salt tolerance.
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