期刊
NEUROSCIENCE LETTERS
卷 740, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2020.135469
关键词
Heterogeneous nuclear ribonuclear protein L-like (hnRNPLL); T cells; Depression; Anxiety; Learning and memory; Prepulse inhibition; Locomotor activity
资金
- Percy Baxter Charitable Trust, Australia
- State Government of Victoria, Australia
The hypomorphic allele of hnRNPLL gene affects immune system and brain function, and the mice model for psychiatric illnesses exhibit behaviors related to depression, impaired spatial memory, and reduced avoidance learning.
Heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) is an RNA binding protein that regulates alternative splicing of mRNA and is abundantly expressed in memory T lymphocytes of the immune system and in the brain. A hypomorphic allele of the gene encoding hnRNPLL (Hnrpll(thunder)) selectively reduces T cell accumulation in lymphoid tissues, but little is known about its effects in the brain. Therefore, we exposed Hnrpll(thunder) mice to a test battery with relevance for a range of psychiatric illnesses. Thunder mice showed enhanced immobility in the tail-suspension test for depression-related behaviours, impaired short-term spatial memory in the Y-maze and reduced avoidance learning in the active avoidance test. Thus, in addition to its reported effects on immune function, the hnRNPLL mutation in thunder mice selectively affected aspects of behaviour.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据