The role of Mrgprs in pain

Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.

Automated summary

The Mas-related G-protein-coupled receptor (Mrgpr) family, known for their functional diversity, plays a role in both itch and pain modulation. Originally characterized in small-diameter nociceptive neurons, recent discoveries suggest that Mrgpr's may provide a new target for the treatment of pathological pain.