期刊
NEUROSCIENCE LETTERS
卷 742, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2020.135545
关键词
Depression; Faces; Emotion; N170; Early posterior negativity (EPN)
资金
- Innovation Cultivating Foundation of The Sixth Medical Center of PLA General Hospital [CXPY201830]
Research findings suggest that MDD patients exhibit altered N170 and EPN components when processing emotional faces, with significantly reduced N170 and delayed/lower EPN compared to the control group. This indicates dysfunction in emotional face processing in MDD patients.
In order to investigate the processes of emotional faces in major depressive disorder (MDD) patients, we recorded and analyzed the N170 and early posterior negativity (EPN) components elicited by schematic faces with happy and angry expressions. It was found that the N170 was significantly reduced in depressive patients than that in the control group, regardless of happy or angry faces. Neither MDD patients nor controls showed the affective effects of N170. The EPN was significantly delayed and lower in MDD patients than that in the control group. In controls, the EPN was significantly enhanced for happy than angry faces, but this emotional effect was not evident in MDD patients. These data provide further electrophysiological evidence for the dysfunction of processing emotional faces in MDD patients.
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