期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 120, 期 -, 页码 48-74出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2020.11.001
关键词
Methamphetamine; Single-nucleotide polymorphism; FAAH; BDNF; Gene-association studies; Meta-analysis; Dependence; Abuse; Neuroscience; Addiction; Psychiatry
资金
- Melbourne Research Scholarship from the University of Melbourne
- National Institutes of Health [P01DA047233]
- NHMRC Senior Principal Research Fellowship [1156072, 1059660]
- NHMRC Principal Research Fellowship [1116930]
- NHMRC Senior Research Fellowship [1154651]
- Brain and Behavior Research Foundation NARSAD young Investigator Award
- National Health and Medical Research Council of Australia [1154651] Funding Source: NHMRC
This review systematically reviewed hypothesis-driven candidate gene association studies related to methamphetamine use disorder. Eleven gene markers were significantly associated with the disorder from adequately powered studies, but limitations include unclear rationale for candidate gene selection, low power and high risk of bias in some studies.
Genetic susceptibility to methamphetamine use disorder is poorly understood. No twin or adequately powered genome-wide association studies (GWASs) have been conducted. However, there are a large number of hypothesis-driven candidate gene association studies, which were systematically reviewed herein. Seventy-six studies were identified, investigating markers of 75 different genes. Allele frequencies, odds ratios, 95 % confidence intervals and power were calculated. Risk of bias was also assessed as a quality measure. Meta-analyses were conducted for gene markers if three or more studies were available. Eleven markers from adequately powered studies were significantly associated with methamphetamine use disorder, with Fatty Acid Amide Hydrolase (FAAH) and Brain Derived Neurotrophic Factor (BDNF) representing promising targets. Limitations of these studies include unclear rationale for candidate gene selection, low power and high risk of bias. Future research should include replications to enable more meta-analyses, well-powered GWASs or whole exome or genome sequencing, as well as twin and family studies to further complement the findings of this review to uncover genetic contributions toward methamphetamine use disorder.
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