期刊
NEUROSCIENCE
卷 452, 期 -, 页码 111-125出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2020.10.031
关键词
unimanual handgrip; fMRI; ipsilateral activation; sensorimotor network; functional connectivity
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [2016-0529]
- NSERC Alexander Graham Bell Canada Graduate Scholarship - Doctoral (CGS D) Awards
- Saskatchewan Health Research Foundation (SHRF) postdoctoral fellowship
- NSERC [183968-2013-22]
Through fMRI studies, it was found that increasing right-handgrip force resulted in greater ipsilateral sensorimotor activation and functional connectivity, correlating with relative handgrip force. High force contractions led to more pronounced network activation and connectivity within the sensorimotor network.
Imaging and brain stimulation studies seem to correct the classical understanding of how brain networks, rather than contralateral focal areas, control the generation of unimanual voluntary force. However, the scaling and hemispheric-specificity of network activation remain less understood. Using fMRI, we examined the effects of parametrically increasing right-handgrip force on activation and functional connectivity among the sensorimotor network bilaterally with 25%, 50%, and 75% maximal voluntary contractions (MVC). High force (75% MVC) unimanual handgrip contractions resulted in greater ipsilateral motor activation and functional connectivity with the contralateral hemisphere compared to a low force 25% MVC condition. The ipsilateral motor cortex activation and network strength correlated with relative handgrip force (% MVC). Increases in unimanual handgrip force resulted in greater ipsilateral sensorimotor activation and greater functional connectivity between hemispheres within the sensorimotor network. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据