期刊
NEUROPSYCHOPHARMACOLOGY
卷 46, 期 5, 页码 1035-1044出版社
SPRINGERNATURE
DOI: 10.1038/s41386-020-00929-9
关键词
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资金
- National Institute of Mental Health [R01MH104648]
- National Institutes of Health (MSTP Training Grant) [T32GM007367]
- Biohaven
This study identified altered functional connectivity in OCD patients between task-positive regions in the temporal gyri and regions of the cingulo-opercular and default networks. Specifically, a lower score in one of the identified independent subcomponents significantly predicted greater symptom reduction with exposure and ritual prevention therapy. These findings suggest that an altered balance between task-positive and task-negative regions may contribute to the difficulty in controlling intrusive thoughts or urge in OCD patients.
Obsessive-compulsive disorder (OCD) is associated with alterations in cortico-striato-thalamo-cortical brain networks, but some resting-state functional magnetic resonance imaging studies report more diffuse alterations in brain connectivity. Few studies have assessed functional connectivity within or between networks across the whole brain in unmedicated OCD patients or how patterns of connectivity predict response to exposure and ritual prevention (EX/RP) therapy, a first-line treatment for OCD. Herein, multiband resting-state functional MRI scans were collected from unmedicated, adult patients with OCD (n = 41) and healthy participants (n = 36); OCD patients were then offered twice weekly EX/RP (17 sessions). A whole-brain-network-based statistic approach was used to identify group differences in resting-state connectivity. We detected altered pre-treatment functional connectivity between task-positive regions in the temporal gyri (middle and superior) and regions of the cingulo-opercular and default networks in individuals with OCD. Signal extraction was performed using a reconstruction independent components analysis and isolated two independent subcomponents (IC1 and IC2) within this altered connectivity. In the OCD group, linear mixed-effects models tested whether IC1 or IC2 values predicted the slope of change in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores across EX/RP treatment. Lower (more different from controls) IC2 score significantly predicted greater symptom reduction with EX/RP (Bonferroni-corrected p = 0.002). Collectively, these findings suggest that an altered balance between task-positive and task-negative regions centered around temporal gyri may contribute to difficulty controlling intrusive thoughts or urges to perform ritualistic behaviors.
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