期刊
NEURON
卷 109, 期 4, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.12.004
关键词
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资金
- Wellcome Trust [209558, 216324]
- Simons Foundation [SCGBAWD543027]
- NIHBRAIN Initiative [NS104899, R01EB026946]
- U19 NIH-NINDS BRAIN Initiative Award [5U19NS104648]
Researchers have introduced a method called PsyTrack that can infer the trajectory of sensory decision-making strategies in animals during learning. By applying this method, they discovered significant differences in the ability of mice, rats, and humans to adapt quickly to changes in sensory stimuli, bias, and task history during the learning process.
Decision-making strategies evolve during training and can continue to vary even in well-trained animals. However, studies of sensory decision-making tend to characterize behavior in terms of a fixed psychometric function that is fit only after training is complete. Here, we present PsyTrack, a flexible method for inferring the trajectory of sensory decision-making strategies from choice data. We apply PsyTrack to training data from mice, rats, and human subjects learning to perform auditory and visual decision-making tasks. We show that it successfully captures trial-to-trial fluctuations in the weighting of sensory stimuli, bias, and task-irrelevant covariates such as choice and stimulus history. This analysis reveals dramatic differences in learning across mice and rapid adaptation to changes in task statistics. PsyTrack scales easily to large datasets and offers a powerful tool for quantifying time-varying behavior in a wide variety of animals and tasks.
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