期刊
NEURON
卷 109, 期 4, 页码 576-596出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.12.008
关键词
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资金
- NARSAD Young Investigator Grant (Brain & Behavior Research Foundation) [28616]
- McDonnell Center for Cellular and Molecular Neurobiology grant [22-3930-26275U]
- Whitehall Foundation Inc. [2020-08-35]
- National Research Foundation of Korea (NRF) [2017R1A2B3011098, 2017M3C7A1023471, 2020R1A4A1019009]
- NIH [1R21NS115437, 5RO1 NS037585-22, 5RO1 NS107315-03, 1RO1 AG061838-01, R35NS105094, R35NS111583, DA047444]
- Medical Research Council, UK [MC_U105170643]
- CHDI Inc.
- Allen Distinguished Investigator Award
- Paul G. Allen Frontiers Group advised grant of the Paul G. Allen Family Foundation
- Ressler Family Foundation
- Khakh lab funds
- [R01 NS053538]
- MRC [MC_PC_17230, MC_U105170643] Funding Source: UKRI
- National Research Foundation of Korea [2020R1A4A1019009, 2017M3C7A1023471, 2017R1A2B3011098] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Astrocytes play crucial roles in the nervous system, regulating neural circuits to affect various behavioral outcomes. Recent studies have uncovered diverse mechanisms of astrocytes and their association with certain human diseases. Including astrocytes in neural circuit research offers new perspectives for understanding behavior, its regulation, and manifestations related to diseases.
Astrocytes are a large and diverse population of morphologically complex cells that exist throughout nervous systems of multiple species. Progress over the last two decades has shown that astrocytes mediate developmental, physiological, and pathological processes. However, a long-standing open question is how astrocytes regulate neural circuits in ways that are behaviorally consequential. In this regard, we summarize recent studies using Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, and Mus musculus. The data reveal diverse astrocyte mechanisms operating in seconds or much longer timescales within neural circuits and shaping multiple behavioral outputs. We also refer to human diseases that have a known primary astrocytic basis. We suggest that including astrocytes in mechanistic, theoretical, and computational studies of neural circuits provides new perspectives to understand behavior, its regulation, and its disease-related Astrocytes are a large and diverse population of morphologically complex cells that exist throughout nervous systems of multiple species. Progress over the last two decades has shown that astrocytes mediate developmental, physiological, and pathological processes. However, a long-standing open question is how astrocytes regulate neural circuits in ways that are behaviorally consequential. In this regard, we summarize recent studies using Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, and Mus musculus. The data reveal diverse astrocyte mechanisms operating in seconds or much longer timescales within neural circuits and shaping multiple behavioral outputs. We also refer to human diseases that have a known primary astrocytic basis. We suggest that including astrocytes in mechanistic, theoretical, and computational studies of neural circuits provides new perspectives to understand behavior, its regulation, and its disease-related manifestations.
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