期刊
NEURON
卷 109, 期 4, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.12.001
关键词
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资金
- European Research Council [NeuroV1sion 616509]
- Swiss National Science Foundation (SNSF) [31003A_169802]
- Wellcome Trust [090843/E/09/Z]
- Gatsby Charitable Foundation [GAT3361]
- EMBO Long-term Fellowship [ALTF 1481-2014]
- HFSP Postdoctoral Fellowship [LT000414/2015-L]
- Branco Weiss-Society in Science grant
- Wellcome Trust [090843/E/09/Z] Funding Source: Wellcome Trust
- Swiss National Science Foundation (SNF) [31003A_169802] Funding Source: Swiss National Science Foundation (SNF)
The intentional control over external objects is influenced by sensory experience. Through a BMI task with mice, it was shown that brain areas can be rapidly reconfigured to exert control over a cursor in a sensory-feedback-dependent manner. The higher visual cortex is more engaged when expert animals control the cursor.
Intentional control over external objects is informed by our sensory experience of them. To study how causal relationships are learned and effected, we devised a brain machine interface (BMI) task using wide-field calcium signals. Mice learned to entrain activity patterns in arbitrary pairs of cortical regions to guide a visual cursor to a target location for reward. Brain areas that were normally correlated could be rapidly reconfigured to exert control over the cursor in a sensory-feedback-dependent manner. Higher visual cortex was more engaged when expert but not naive animals controlled the cursor. Individual neurons in higher visual cortex responded more strongly to the cursor when mice controlled it than when they passively viewed it, with the greatest response boosting as the cursor approached the target location. Thus, representations of causally controlled objects are sensitive to intention and proximity to the subject's goal, potentially strengthening sensory feedback to allow more fluent control.
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