4.7 Article

Brain topography beyond parcellations: Local gradients of functional maps

期刊

NEUROIMAGE
卷 229, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.117706

关键词

Parcellation; Functional mapping; Prediction; Model selection; Functional gradients

资金

  1. European Union's Horizon 2020 Framework Program for Research and Innovation [945539]
  2. KARAIB AI chair [ANR-20-CHIA-0025-01]
  3. McDonnell Center for Systems Neuroscience at Washington University
  4. [1U54MH091657]
  5. Agence Nationale de la Recherche (ANR) [ANR-20-CHIA-0025] Funding Source: Agence Nationale de la Recherche (ANR)

向作者/读者索取更多资源

Functional neuroimaging allows characterization of brain spatial organization based on response to tasks or ongoing activity, with the concept of organization remaining elusive. Researchers quantitatively assessed local gradient-based models to predict functional features, developing a parcel-wise linear regression model based on reference topographies. Multiple random parcellations were used to predict functional features, demonstrating the existence of an optimal grouping for capturing local gradients.
Functional neuroimaging provides the unique opportunity to characterize brain regions based on their response to tasks or ongoing activity. As such, it holds the premise to capture brain spatial organization. Yet, the conceptual framework to describe this organization has remained elusive: on the one hand, parcellations build implicitly on a piecewise constant organization, i.e. flat regions separated by sharp boundaries; on the other hand, the recently popularized concept of functional gradient hints instead at a smooth structure. Noting that both views converge to a topographic scheme that pieces together local variations of functional features, we perform a quantitative assessment of local gradient-based models. Using as a driving case the prediction of functional Magnetic Resonance Imaging (fMRI) data -concretely, the prediction of task-fMRI from rest-fMRI maps across subjects- we develop a parcel-wise linear regression model based on a dictionary of reference topographies. Our method uses multiple random parcellations -as opposed to a single fixed parcellation- and aggregates estimates across these parcellations to predict functional features in left-out subjects. Our experiments demonstrate the existence of an optimal cardinality of the parcellation to capture local gradients of functional maps.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据