4.7 Article

The nonhuman primate neuroimaging and neuroanatomy project

期刊

NEUROIMAGE
卷 229, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2021.117726

关键词

Functional MRI; Diffusion MRI; Retrograde tracer; Connectivity; Connectome; Hierarchy; Marmoset; Macaque; Human

资金

  1. Japan Agency of Medical Research and Development (AMED) [JP20dm0307006h0002]
  2. grant KAKENHI from MEXT [19H04904]
  3. NIH [MH060974, RF1 MH116978, P50NS098573]
  4. Wellcome Trust
  5. SBRI [LABEX CORTEX ANR-11 -LABX-0042]
  6. Universitede Lyon [ANR-11-IDEX-0007]
  7. Region Auvergne-Rhone-Alpes [SCUSI 1700933701]
  8. Chinese Academy of Sciences President's International Fellowship Initiative [2018VBA0011]
  9. DUAL_STREAMS [ANR-19-CE37-0025]
  10. A2P2MC [ANR-17-NEUC-0004]
  11. CORTICITY [ANR-17-HBPR-0003]
  12. Grants-in-Aid for Scientific Research [19H04904] Funding Source: KAKEN
  13. Agence Nationale de la Recherche (ANR) [ANR-19-CE37-0025, ANR-17-NEUC-0004, ANR-17-HBPR-0003] Funding Source: Agence Nationale de la Recherche (ANR)

向作者/读者索取更多资源

Studies using nonhuman primates (NHPs) enable comparisons between invasive and non-invasive measures to better understand human brain connectivity and structure.
Multi-modal neuroimaging projects such as the Human Connectome Project (HCP) and UK Biobank are advancing our understanding of human brain architecture, function, connectivity, and their variability across individuals using high-quality non-invasive data from many subjects. Such efforts depend upon the accuracy of non-invasive brain imaging measures. However, 'ground truth' validation of connectivity using invasive tracers is not feasible in humans. Studies using nonhuman primates (NHPs) enable comparisons between invasive and non-invasive measures, including exploration of how functional connectivity from fMRI and tractographic connectivity from diffusion MRI compare with long-distance connections measured using tract tracing. Our NonHuman Primate Neuroimaging & Neuroanatomy Project (NHP_NNP) is an international effort (6 laboratories in 5 countries) to: (i) acquire and analyze high-quality multi-modal brain imaging data of macaque and marmoset monkeys using protocols and methods adapted from the HCP; (ii) acquire quantitative invasive tract-tracing data for cortical and subcortical projections to cortical areas; and (iii) map the distributions of different brain cell types with immunocytochemical stains to better define brain areal boundaries. We are acquiring high-resolution structural, functional, and diffusion MRI data together with behavioral measures from over 100 individual macaques and marmosets in order to generate non-invasive measures of brain architecture such as myelin and cortical thickness maps, as well as functional and diffusion tractography-based connectomes. We are using classical and next-generation anatomical tracers to generate quantitative connectivity maps based on brain-wide counting of labeled cortical and subcortical neurons, providing ground truth measures of connectivity. Advanced statistical modeling techniques address the consistency of both kinds of data across individuals, allowing comparison of tracer-based and non-invasive MRI-based connectivity measures. We aim to develop improved cortical and subcortical areal atlases by combining histological and imaging methods. Finally, we are collecting genetic and sociality-associated behavioral data in all animals in an effort to understand how genetic variation shapes the connectome and behavior.

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