期刊
NEUROIMAGE
卷 229, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2021.117737
关键词
Redundancy; Brain reserve; Aging; Network analysis; Executive function
资金
- National Institute on Aging of the National Institutes of Health [R01AG062590]
Functional network redundancy shows a significant association with age over the human lifespan, with a stronger link than other major topological measures. The accumulation of redundancy in midlife followed by a decline in old age mediates the association between age and executive function, suggesting that functional redundancy plays a role in mitigating the effects of age on cognition.
Despite the necessity to understand how the brain endures the initial stages of age-associated cognitive decline, no brain mechanism has been quantitatively specified to date. The brain may withstand the effects of cognitive aging through redundancy, a design feature in engineered and biological systems, which entails the presence of substitute elements to protect it against failure. Here, we investigated the relationship between functional network redundancy and age over the human lifespan and their interaction with cognition, analyzing resting-state functional MRI images and cognitive measures from 579 subjects. Network-wide redundancy was significantly associated with age, showing a stronger link with age than other major topological measures, presenting a pattern of accumulation followed by old-age decline. Critically, redundancy significantly mediated the association between age and executive function, with lower anti-correlation between age and cognition in subjects with high redundancy. The results suggest that functional redundancy accrues throughout the lifespan, mitigating the effects of age on cognition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据