Assessment of pyloric sphincter distensibility and pressure in patients with diabetic gastroparesis

Background Recent studies have shown that pyloric distensibility is altered in 30-50% of gastroparetic patients but the number of diabetic patients included in prior reports has been small. The aim of the present study was to assess pyloric sphincter measurements in diabetic patients with gastroparesis and to determine whether diabetes characteristics were correlated to pyloric disfunction. Methods Pyloric distensibility and pressure were measured using EndoFLIP(R) system in 46 patients with diabetic gastroparesis (DGP) and compared with 21 healthy volunteers (HV), and 33 patients with idiopathic gastroparesis (IGP). Altered pyloric distensibility was defined as the measurement below 10 mm(2)/mmHg at 40 ml of inflation. In diabetic patients, blood glucose, glycated hemoglobin, duration, complications, and treatments were collected. Key Results Mean pyloric distensibility at 40 ml of inflation was lower in DGP and IGP groups with, respectively, 10.8 +/- 0.9 mm(2)/mmHg and 14.8 +/- 2.2 mm(2)/mmHg in comparison with the HV group (25.2 +/- 2.3 mm(2)/mmHg; p < 0.005). 56.5% of patients had a decreased pyloric distensibility in the DGP group, 51.5% of patients in the IGP group, and 10% of patients in the HV group. No correlation was found between pyloric sphincter measurements and diabetes characteristics, including blood glucose, glycated hemoglobin, diabetes mellitus type, neuropathy, or GLP1 agonists intake. Conclusion and Interferences Pyloric sphincter distensibility and pressure were altered both in diabetic and idiopathic gastroparesis. Pyloric sphincter distensibility was not correlated to diabetes parameters.

Automated summary

Recent studies have shown that pyloric distensibility is altered in 30-50% of gastroparetic patients, but the correlation between pyloric sphincter measurements and diabetes characteristics was not found in this study. Both diabetic and idiopathic gastroparesis showed altered pyloric sphincter distensibility and pressure.