期刊
NEUROCHEMICAL RESEARCH
卷 46, 期 2, 页码 287-298出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-020-03163-3
关键词
High-fat diet; Coconut oil; Neuroinflammation; Object– place test
资金
- Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah [G-557-140-38]
Research indicates that a high-fat diet can lead to neuroinflammation and impaired spatial memory, while a diet high in coconut oil does not induce neuroinflammation.
The consumption of high-fat and high-sugar diets, in the form of junk food, and binge eating are now common. Increasing evidence suggests that a high-fat diet (HFD) can induce neuroinflammation and alter behavior. I aimed to study the effects of diets of differing fat content on neuroinflammation and spatial memory using an object-place (OP) task. Thirty-two adult male rats were allocated to four groups and fed a regular diet (Regular diet), a control diet (Control diet), an HFD (60% of calories from lard), or a high-coconut oil diet (HCOD; 60% of calories from coconut oil) for 3 days. Their water intake, food consumption, body mass, and metabolic variables were measured. HFD-fed rats showed significantly poorer performance on the OP task, as assessed using the discrimination index (- 0.208 +/- 0.094), than the Regular (0.462 +/- 0.078; P < 0.0001) and Control (0.379 +/- 0.081; P = 0.0003) groups. However, no significant difference was observed in spatial memory between the HCOD and Regular groups. The concentrations of neuroinflammatory markers (interleukin [IL]-1 beta, IL-6, tumor necrosis factor alpha, and nuclear factor kappa B) were also measured in the hippocampus and prefrontal cortex. HFD-fed rats showed significantly higher levels of neuroinflammatory markers than the Regular and Control diet-fed groups. HCOD feeding did not induce neuroinflammation in the hippocampus and prefrontal cortex compared with the Regular and Control groups.
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