期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 177, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2020.107361
关键词
Development; Recognition memory; Rodents; Novel object recognition; Object location; Temporal order recognition
资金
- CIHR [399790] Funding Source: Medline
This review examines the expression of spontaneous recognition memory in young rodents through analyzing studies using four different tasks. Variability between studies is identified and classified, leading to exploration of the ontogeny and neural correlates of each task, with implications for cognitive assessment and potential intervention strategies.
Spontaneous recognition memory tasks explore the what, where and when components of recognition memory. These tasks are widely used in rodents to assess cognitive function across the lifespan. While several neurodevelopmental and mental disorders present symptom onset in early life, very little is known about how memories are expressed in early life, and as a consequence how they may be affected in pathological conditions. In this review, we conduct an analysis of the studies examining the expression of spontaneous recognition memory in young rodents. We compiled studies using four different tasks: novel object recognition, object location, temporal order recognition and object place. First, we identify major sources of variability between early life spontaneous recognition studies and classify them for later comparison. Second, we use these classifications to explore the current knowledge on the ontogeny of each of these four spontaneous recognition memory tasks. We conclude by discussing the possible implications of the relative time of onset for each of these tasks and their respective neural correlates. In compiling this research, we hope to advance on establishing a developmental timeline for the emergence of distinct components of recognition memory, while also identifying key areas of focus for future research. Establishing the ontogenetic profile of rodent spontaneous recognition memory tasks will create a necessary blueprint for cognitive assessment in animal models of neurodevelopmental and mental disorders, a first step towards improved and earlier diagnosis as well as novel intervention strategies.
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