☆ 4.6 Editorial Material

Breaking down the blood-brain barrier

NEURO-ONCOLOGY (2021)

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NEO100 enables brain delivery of blood-brain barrier impermeable therapeutics

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Summary: NEO100 was found to safely and reversibly open the BBB, allowing for increased brain entry of various therapeutics in both in vitro and in vivo models. Mechanistic studies revealed its effects on different BBB transport pathways and the translocation of tight junction proteins in brain endothelial cells. This approach has the potential to provide a safe and widely available method to enhance brain entry of therapeutics.

NEURO-ONCOLOGY (2021)

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